Medical Literature - 1973

A family study of hereditary angioneurotic oedema

Beck P, Willis D, Davies GT, Lachmann PJ, Sussman M 4/1973 Q.J.Med.


Hereditary angioneurotic oedema is a rare condition inherited as an autosomal dominant and characterized by episodic circumscribed oedema of the skin, subcutaneous tissues, or mucous membranes. Life may be threatened when the pharynx or larynx are involved and oedema of the intestinal mucous membrane, presenting as colicky abdominal pain and vomiting, may lead to unnecessary surgical intervention. The condition is due to deficiency of the functional inhibitor of the activated first component of complement. Consumption of the inhibitor by activation of other plasma esterase systems permits spontaneous activation of the initial stages of the complement system and leads to the appearance of a kinin derived from the second component of complement which causes oedema by increasing vascular permeability.

Four patients in three generations of a family with hereditary angioneurotic oedema are presented with special reference to attacks of abdominal colic. The clinical and radiological appearances and serological changes are described before, during, and after treatment by transfusion of fresh-frozen plasma. It was confirmed that this, by replacing the inhibitor, is highly effective in terminating attacks without significant side-effects. It was also confirmed by a controlled trial that epsilon-aminocaproic acid acts prophylactically by reducing the frequency and severity of attacks of oedema.

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Familial angiooedema treated with epsilon aminocaproic acid

Williamson DM. 5/1973 British Journal of Clinical Practice


Not available online.

Hereditary angio-neurotic oedema. Genealogical and immunological studies.

Ohela K, Rasanen JA, Wager O. 6/1973 Annals of Clinical Research


Not available online.

Hereditary angio-oedema (HAO)

Felix RH. 5/1973 Proceedings of the Royal Society of Medicine


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Hereditary angioneurotic oedema

7/1973 Lancet

Jul 7;2(7819):41.

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Hereditary angioneurotic oedema

5/1973 Lancet

May 12;1(7811):1044-1045.

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Hereditary angioneurotic oedema

Agostoni A, Martignoni GC. 8/1973 Lancet


Available online at: (small fee)

Hereditary angioneurotic oedema

Brackertz D, Kueppers F. 9/1973 Lancet


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Hereditary angioneurotic oedema

Calvert GD, Kilpatrick D, McQueen EG, Houston IB, Kilpatrick JA, Veale AM. 10/1973 N.Z.Med.J.

Oct 24;78(501):337-342.

Not available online.

Hereditary angioneurotic oedema

Keller MF. 6/1973 Lancet

Jun 16;1(7816):1381-1382.

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Possible therapy in hereditary angioneurotic edema (HAE)

Brackertz D, Kueppers F. 6/1973 Klin.Wochenschr.


The symptomatic therapy of hereditary angioneurotic edema with tranexamic acid and suramin in two patients is reported. The first patient responded well to tranexamic acid (Cyclocapron®) but not to suramin. In the second patient, attacks of edema could apparently be better prevented with suramin.

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Tranexamic acid in hereditary angioneurotic edema–a progress report

Lundh B. 1/1973 The New England Journal of Medicine

Jan 4;288(1):53.

Available online at: (small fee)

Funding for Canadian Hereditary Angioedema Network has been generously provided by unrestricted grants from:


CSL Behring


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