Medical Literature - 1974

Hereditary angioneurotic edema. Treatment with epsilon-aminocaproic acid during surgery.

Johns ME, Vanselow MA, Boles R. 5/1974 Archives of Otolaryngology


Not available online.

Letter: Hereditary angioneurotic oedema

Erill S, Cabezas R, VAusina 2/1974 Lancet

Feb 2;1(7849):169.

Available online at: (small fee)

Long-term therapy of hereditary angioedema (HAE). Preventive management with fluoxymesterone and oxymetholone in severely affected males and females.

Davis PJ, Davis FB, Charache P. 12/1974 Johns Hopkins Med.J.


Not available online.

Prophylactic use of epsilon aminocaproic acid for oral surgery in a patient with hereditary angioneurotic edema

Pence HL, Evans R, Guernsey LH, Gerhard RC. 5/1974 Journal of Allergy & Clinical Immunology


A case is reported for the first time of a patient with hereditary angioneurotic edema who had oral surgery and teeth extractions while being treated with epsilon aminocaproic acid (EACA). The mechanism of action and possible further use of this medication for similar clinical situations are discussed.

Available online at:

Therapy in hereditary angioneurotic oedema

Gwynn CM. 8/1974 Archives of Disease in Childhood


“Two branches of a family suffering from hereditary angioneurotic oedema underwent trials of therapy of ε-amino caproic-acid (EACA) to ascertain the optimum dosage required to alleviate symptoms without giving rise to unpleasant side effects.

It was found that children under 11 years tolerated 3 g/day and patients over 11 years 6 g/day without side effects, but with incomplete control of symptoms in some of the patients. However, if the dose was doubled for a period of less than 4 days during times of expected and experienced trauma, better control was achieved and unpleasant muscle cramps were not experienced. These doses, though effective, were much smaller than those used in previous studies.”

Available online at:

Funding for Canadian Hereditary Angioedema Network has been generously provided by unrestricted grants from:


CSL Behring


Contact Us

20 Carlton Street, Suite 123
Toronto, ON M5B 2H5
Tel: 416-585-3000

Patient Images

Patient Images

Copyright © 2024 CHAEN-RCAOH

All rights reserved.

Privacy Policy

Powered by Wild Apricot Membership Software