Medical Literature - 1980

Danazol therapy in hereditary angioedema

Sweet LC, Jackson CE, Yanari SS, Yott JB 1/1980 Henry Ford Hospital Medical Journal


Not available online.

Danazole in the treatment of hereditary angioedema

Hosea SW, Frank MM. 5/1980 Drugs


Danazol is an effective agent for the prophylaxis of the recurrent attacks of mucocutaneous and visceral swelling which occur in patients with hereditary angioedema (HAE). Danazol apparently increases the synthesis of the inhibitor of the first component of complement which is partially deficient in these heterozygous individuals. The efficacy of danazol in this condition appears to be limited only by the occurrence of adverse effects. [References: 6].

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Hereditary angio-oedema: its pathogenesis and management

Ballogh Z, Whaley K. 7/1980 Scottish Medical Journal


Hereditary angio-oedema is a genetically-determined disease. Usually the disease is due to a deficiency of C1-inhibitor or less commonly to the production of a functionally inactive molecule. The pathogenesis and clinical features of the disease are reviewed, and discussed in relation to the homeostatic role of C1 inhibitor. Finally the therapeutic approach to the disease is described and the scientific bases for the newer therapeutic discussed.

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Hereditary angioneurotic edema and its correction with androgen therapy

Rosen FS, Beyler A. 1/1980 Birth Defects: Original Article Series


Not available online.

Long-term therapy of hereditary angioedema with danazol

Hosea SW, Santaella ML, Brown EJ, Berger M, Katusha K, Frank MM. 12/1980 Annals of Internal Medicine


We treated 69 patients who had hereditary angioedema with danazol to alleviate attacks of mucocutaneous angioedema involving the skin, oropharynx, and gastrointestinal tract, and we documented the continued efficacy of danazol for long-term treatment (1 to 6 years) of hereditary angioedema. Significant dose-related, adverse reactions occurred, including weight gain, myalgias, headaches, microscopic hematuria, abnormal liver function tests, anxiety, altered libido, alopecia, dizziness, and nausea. Alterations in menstrual function were consistently observed. About 10% of patients noted masculinizing side effects, such as acne, hirsutism, and voice deepening. We recommend downward titration of danazol dosage to achieve control of attacks and minimize adverse reactions. Periodic monitoring of patients on long-term danazol therapy is essential to avoid undesirable toxicity.

Available online at: (small fee)

The use and misuse of androgens

Wilson JD, Griffin JE 12/1980 Metabolism: Clinical & Experimental

Because testosterone is rapidly metabolized by the liver, it is necessary either to administer androgens by injection in the form of testosterone esters that are absorbed slowly into the circulation or to administer by mouth derivatives that are slowly metabolized by the liver. The later derivatives, however, have deleterious side effects that limit their usefulness. Long-acting parenteral androgen esters are the treatment of choice in the replacement therapy of male hypogonadism. Because these esters must be hydrolyzed to the free hormone prior to exerting their cellular actions the effectiveness of therapy can be monitored by following plasma testosterone levels. All known effects of the endogenous hormone can be duplicated except for the induction and maintenance of normal spermatogenesis. Androgens have been tried in a variety of clinical situations other than male hypogonadism in the hopes that the nonvirilizing actions would outweigh any detectable side effects. The only disorders in which a salutary effect has been documented are hereditary angioneurotic edema and some patients with anemia due to failure off the bone marrow. [References: 224].


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Treatment of acute attacks of hereditary angioedema with C1-inhibitor concentrate

Agostoni A, Bergamaschini L, Martignoni G, Cicardi M, Marasini B. 5/1980 Annals of Allergy, Asthma & Immunology


Attacks of laryngeal edema in patients with hereditary angioedema (HAE) have been successfully treated with the infusion of C1-inhibitor (C1-INH) concentrate. No side effects were observed.

Not available online.

Treatment of hereditary angio-oedema by low dose attenuated androgens: disassociation of clinical response from levels of C1 esterase inhibitor and C4

Warin AP, Greaves MW, Gatecliff M, Williamson DM, Warin RP 10/1980 British Journal of Dermatology

Nine patients with hereditary angio-oedema (H.A.E.) with a deficiency of C1 esterase inhibitor (C1 INH), have been treated with low dose attenuated androgenic drugs, with complete control of their disease. The C1 esterase inhibitor and C4 levels became normal in only one patient. It is concluded that H.A.E. can be controlled in the absence of correction of the reduced levels of C1 INH and C4. The mode of action of these drugs appears to be more complex than is generally realized.


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Treatment of hereditary angioneurotic oedema with Danazol

van Royen EA, Hannema A, Cormane RH, Pondman KW 1/1980 The Netherlands Journal of Medicine (MJM)


Not available online.

Funding for Canadian Hereditary Angioedema Network has been generously provided by unrestricted grants from:


CSL Behring


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